Individuals with advanced untreated HIV infection or acquired immunodeficiency syndrome (AIDS).Individuals with moderate to severe primary immunodeficiency (for example, DiGeorge syndrome, Wiskott-Aldrich syndrome).
Recipients of chimeric antigen receptor (CAR)-T-cell therapy.Individuals with certain immunocompromising conditions should receive a 3-dose primary series, followed by all of the booster doses they are eligible for. This is to provide stronger protection because their immune systems respond differently to vaccines than other people without these conditions.
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